DOSAGE INDEX / SINGLE
HMG
Research, reported schedules and supply planning.
Review HMG and menotropins evidence, the MERIT fertility trial, combination treatment research and the limits of comparing pregnancy rates.
Source: PeptideDosages.com. Independently written summaries of reported protocols, not validated treatment recommendations. Reviewed for transcription on September 21, 2026.
Research Protocol & Dosage
Source-reported examples · not treatment recommendations
- Amount
- 75 IU per administration
- Frequency
- Three times weekly
- Cycle / observation period
- 12 weeks; source also mentions 16 weeks
- Route / research model
- Subcutaneous
The source uses sterile 0.9% sodium chloride. Its parenthetical mass value is not a universal conversion between mg and IU.
Titration & progression
The selected example uses a fixed amount; no stepwise titration is specified for this planning window.
| Phase | Amount per administration | Frequency |
|---|---|---|
| Days 1–84 | 75 IU | 3 times per week |
Supply & Planning
Compare vial strengths here. A different vial size changes the available material, not the biological dose.
Diluent & formulation
Product-specific diluent exception is awaiting confirmation. No substitution between sterile saline and bacteriostatic saline has been assigned.
Vial comparison
Source example: 84-day planning window: 2700 IU total material. Use this total below, or enter a different documented total for comparison.
| Vial strength | Vials needed |
|---|---|
| 75 IU | 36 |
Calculated from the displayed schedule.
Material minimum only: round total material ÷ vial content up to a whole vial. Actual supply may be higher because of single-use packaging, discard dates, dead space or losses. No validated multi-use storage period is assumed.
Reported Research Results
Selected observations from the cited research. Each finding retains its study population, formulation and limitations.
- The MERIT study randomized 731 women undergoing IVF after a long GnRH-agonist protocol to highly purified HMG or recombinant FSH. Ongoing pregnancy rates per cycle were 27% and 22%, respectively. The confidence interval did not establish superiority of HMG, although the study met its noninferiority criterion. Recombinant FSH yielded more retrieved oocytes, while the HMG group had a higher proportion classified as top-quality embryos. Ferring sponsored the study. [1]
- A small study of 18 males investigated combined HCG and HMG in hypogonadotrophic hypogonadism. Hormone and sperm responses varied across diagnostic subgroups, and fertility was reported in only three participants. Because both agents were used, this is not an isolated test of HMG's contribution. [2]
- MENOPUR labeling warns about ovarian hyperstimulation syndrome, multiple gestation, ovarian torsion and pulmonary or vascular complications. It calls for experienced infertility care and appropriate monitoring facilities. Severe abdominal or pelvic pain, rapid weight gain, breathing difficulty or markedly reduced urination warrant urgent medical assessment in this setting. [3]
Sourcing & Vendor Information
No compound-specific affiliate destination is listed here yet. Browse the Vendors Index for the available supplier records and disclosed relationships.
Sources & Further Reading
Medical publications and supporting literature from the corresponding protocol bibliographies, combined across vial strengths. Supplier and commercial catalog references are excluded. Duplicate destinations appear once. Inclusion does not mean that a paper validates the reported dose, or that an ingredient study tests the finished blend.
Bibliography checked September 22, 2026: 10 entries mapped from 1 source page. Medical and supporting references are retained below; supplier entries are excluded.
- Original MERIT report
- Original combination study
- Full prescribing information and patient instructions
- ASRM Practice Committee 2020 – Gonadotropin Use for Ovulation InductionFurther reading · Listed in reference bibliography.
- ASRM Patient Fact Sheet – Medications for Inducing OvulationFurther reading · Listed in reference bibliography.
- International Journal of Reproductive BioMedicine (Iran JRM, 2014)No destination link supplied in the source bibliography.Further reading · Listed in reference bibliography.
- MedlinePlus – Subcutaneous Injection InstructionsGeneral guidance · Listed in reference bibliography.
- Reproductive Medicine and Biology (2018) – Gonadotropin Therapy for Male InfertilityFurther reading · Listed in reference bibliography.
Reported schedule reference: PeptideDosages.com. Research findings are summarized independently from the listed sources.