.header nav ul{display:flex;gap:22px;align-items:center;list-style:none;padding:0;margin:0;flex-wrap:wrap}.header nav li{margin:0}.pi-index-hubs{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px;padding-top:32px;padding-bottom:32px}.pi-index-hubs>a{padding:28px;text-decoration:none;border:1px solid #c9d9d0;border-radius:14px;background:#e8f3ed;color:#20382e}.pi-index-hubs>a:nth-child(2){background:#efebfa}.pi-index-hubs>a:nth-child(3){background:#fff1d8}.pi-index-hubs h2{font-size:26px;line-height:1.2}.pi-index-hubs span{font:12px monospace;letter-spacing:.08em}.pi-compound-routes{display:flex;gap:14px;flex-wrap:wrap;padding:16px 0}.pi-compound-routes a{padding:8px 12px;border:1px solid #9db5a7;border-radius:8px;font-size:15px}.pi-question-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:24px;margin:32px 0}.pi-question-grid>section{padding:28px;background:#f0f6f2;border-radius:14px;border:1px solid #d3e0d8}.pi-question-grid>section:nth-child(2){background:#f2edfa}.pi-question-grid>section:nth-child(3){background:#fff4e3}.pi-question-grid h2{font-size:27px;line-height:1.25}.pi-question-grid p{line-height:1.7}.pi-evidence-badge{display:inline-block;padding:5px 10px;border-radius:20px;background:#d5e8df;font-size:14px;font-weight:600}.pi-review-note{font-size:13px;color:#4d6257}.pi-protocol-browser{margin-top:50px}.pi-protocol-browser label{display:block;margin:14px 0 6px}.pi-protocol-browser input,.pi-protocol-browser select{font:inherit;padding:14px;width:100%;max-width:600px;border:1px solid #9aada0;border-radius:6px;background:#fff;color:#20382e}.pi-protocol-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}.pi-protocol-card{display:block;padding:24px;border:1px solid #c9d9d0;border-radius:12px;text-decoration:none;background:#fff;color:#20382e}.pi-protocol-card span{font-size:12px;letter-spacing:.03em;color:#546859}.pi-protocol-card h3{font-size:24px;line-height:1.2;margin:12px 0}.pi-protocol-card:hover,.pi-index-hubs>a:hover{border-color:#315947;background:#eaf4ed}.pi-protocol-card:focus-visible,.pi-index-hubs>a:focus-visible{outline:3px solid #315947;outline-offset:3px}.pi-protocol-card[hidden],.pi-protocol-empty[hidden]{display:none!important}.pi-protocol-index{overflow-wrap:anywhere}.pi-sourcing{max-width:1000px}.pi-vendor-option{padding:20px;border:1px solid #cadbce}.pi-protocol-index .lede{max-width:800px}@media(max-width:850px){.pi-index-hubs,.pi-protocol-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.header nav ul{gap:12px}.header nav a{font-size:14px}}@media(max-width:600px){.pi-index-hubs,.pi-protocol-grid,.pi-question-grid{grid-template-columns:1fr}.pi-question-grid>section{padding:20px}.header nav ul{justify-content:center;gap:12px}.pi-protocol-index h1{font-size:36px}.pi-index-hubs h2{font-size:25px}}
.pi-concentration label{display:block;margin:16px 0 6px}.pi-concentration input{display:block;width:100%;max-width:420px;padding:12px;font:inherit;border:1px solid #9aada0;border-radius:6px}.pi-concentration{max-width:1000px}.pi-question-grid{align-items:start}

.pi-question-grid>section{min-width:0}.pi-dose-table{overflow-x:auto;max-width:100%;margin:20px 0}.pi-dose-table table{width:100%;border-collapse:collapse;font-size:15px;line-height:1.5}.pi-dose-table caption{text-align:left;font-weight:600;padding-bottom:12px}.pi-dose-table th,.pi-dose-table td{text-align:left;vertical-align:top;padding:12px;border-bottom:1px solid #c9bfd9}.pi-dose-table th{background:#e4dced}.pi-dose-table tbody tr:nth-child(even){background:#ffffff70}

.pi-source-facts{margin:24px 0}.pi-source-facts dt{font-size:12px;letter-spacing:.07em;text-transform:uppercase;font-weight:700;margin-top:20px;color:#614a78}.pi-source-facts dd{margin:6px 0 16px;font-size:18px;line-height:1.6}.pi-source-context{padding:16px;border-left:3px solid #997044;background:#fff4df;border-radius:4px}.pi-source-strength{font-weight:600;color:#354d63}.pi-source-card[data-status=single]{border-top:5px solid #6b9b85}.pi-source-card[data-status=blend]{border-top:5px solid #a38ac3}.pi-source-card[data-status=stack]{border-top:5px solid #d8a05a}.pi-source-links{display:flex;flex-wrap:wrap;gap:12px;margin:24px 0}.pi-source-links a{padding:12px 16px;border:1px solid #b6c8bd;border-radius:8px}.pi-source-related{margin:32px 0 48px}
.pi-source-hero{position:relative;display:grid;grid-template-columns:minmax(0,1.55fr) minmax(240px,.65fr);gap:50px;align-items:center;padding:clamp(28px,5vw,68px);border:1px solid #bdd1c2;border-radius:24px;background:radial-gradient(ellipse at top right,#d0e4cb 0,transparent 60%),linear-gradient(135deg,#f0f6ef,#e1eee7);overflow:hidden;margin:6px 0 18px}.pi-source-hero h1{font-size:clamp(48px,6vw,88px);line-height:1.04;letter-spacing:-.055em;margin:20px 0 26px}.pi-source-hero h1 span{color:#b88648}.pi-source-hero .lede{font-size:clamp(25px,3vw,38px);line-height:1.25;color:#2c4d3b;margin:0 0 22px}.pi-hero-copy{max-width:540px;line-height:1.75;font-size:17px;color:#435c50}.pi-source-cta{display:inline-flex;gap:32px;align-items:center;margin-top:14px;padding:16px 22px;background:#294c3b;color:#fff!important;border-radius:8px;text-decoration:none;font-weight:600}.pi-source-cta:hover{background:#193d2b}.pi-source-cta span{font-size:23px}.pi-library-stats{position:relative;background:#ffffffe3;border:1px solid #c4d5c6;border-radius:18px;padding:30px;box-shadow:0 18px 45px #305e3910;transform:rotate(2deg)}.pi-stat-label,.pi-stat-date{display:block;font:11px monospace;letter-spacing:.12em;color:#597265}.pi-library-stats>strong{display:block;font-size:96px;font-weight:400;line-height:1.1;letter-spacing:-.08em;margin:22px 0 4px;color:#32523c}.pi-library-stats>span:not(.pi-stat-label):not(.pi-stat-date){font-size:18px}.pi-library-stats>div{border-top:1px solid #d9e2d8;margin-top:24px;padding-top:10px}.pi-library-stats p{font-size:14px;line-height:1.5;display:flex;gap:14px;align-items:center}.pi-library-stats b{font-size:25px;font-weight:500;min-width:36px;color:#5b5276}.pi-stat-date{border-top:1px solid #d9e2d8;margin-top:16px;padding-top:18px;letter-spacing:.04em}.pi-source-index>.pi-review-note{max-width:950px;font-size:12px;line-height:1.65;margin:16px 0 28px}.pi-source-guide-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px;margin:36px 0 72px}.pi-source-guide-grid>a{position:relative;display:block;padding:27px 27px 48px;border:1px solid #dbd4e7;border-radius:14px;background:#f0ecf7;text-decoration:none;color:#302b3e}.pi-source-guide-grid>a:nth-child(2){background:#fff2df;border-color:#e7d8be}.pi-source-guide-grid>a:nth-child(3){background:#e8f0f5;border-color:#cbdce5}.pi-source-guide-grid span{font:10px monospace;letter-spacing:.09em}.pi-source-guide-grid h2{font-size:24px;line-height:1.25;margin:20px 0 14px;letter-spacing:-.025em}.pi-source-guide-grid p{font-size:14px;line-height:1.7;margin:0}.pi-source-guide-grid b{position:absolute;bottom:18px;right:24px;font-size:23px;font-weight:400}.pi-source-guide-grid a:hover{transform:translateY(-3px);box-shadow:0 8px 20px #1d35200c}.pi-source-browser{scroll-margin-top:36px}.pi-source-browser h2{font-size:clamp(29px,4vw,44px);letter-spacing:-.035em;line-height:1.15;margin:16px 0}.pi-source-browser>p:not(.eyebrow){color:#516359}.pi-source-toolbar{display:grid;grid-template-columns:minmax(0,1.6fr) minmax(230px,1fr);gap:18px;padding:22px 24px 26px;background:#eef2ec;border:1px solid #d4ddd0;border-radius:12px;margin-top:28px}.pi-source-toolbar label{font-size:13px;font-weight:600;margin-top:0}.pi-source-toolbar input,.pi-source-toolbar select{max-width:none;height:55px;font-size:16px}.pi-source-alphabet{display:flex;flex-wrap:wrap;gap:5px;padding:22px 0 14px}.pi-source-alphabet button{font-family:inherit;font-size:13px;min-width:32px;height:34px;padding:0 8px;border:1px solid #d0dcd3;background:transparent;color:#385443;border-radius:5px;cursor:pointer}.pi-source-alphabet button[aria-pressed=true]{background:#355a43;color:#fff;border-color:#355a43}.pi-source-result-bar{display:flex;gap:20px;justify-content:space-between;align-items:center;margin-bottom:20px}.pi-source-result-bar p{font-size:13px;margin:0;color:#617166}.pi-source-reset{font-family:inherit;font-size:13px;padding:8px 0;border:0;background:transparent;color:#345846;text-decoration:underline;cursor:pointer}.pi-source-card{position:relative;padding:24px 24px 20px;min-height:190px;transition:transform .15s,box-shadow .15s}.pi-source-card h3{margin:18px 0 14px;font-size:23px;line-height:1.25;letter-spacing:-.02em}.pi-source-card>span{font:10px monospace;text-transform:uppercase;letter-spacing:.13em}.pi-source-card>p:last-child{font-size:12px;line-height:1.6;margin-bottom:0;color:#5e6e63}.pi-source-card:hover{transform:translateY(-3px);box-shadow:0 8px 20px #223d2910;background:#fff}.pi-source-strength{font-size:16px;margin:0 0 20px}.pi-source-more{display:block;margin:32px auto 0;padding:14px 30px;border:1px solid #365d46;background:#355a43;color:#fff;border-radius:8px;font:inherit;cursor:pointer}.pi-source-more[hidden]{display:none}.pi-source-reading{padding:38px;border:1px solid #cddad1;border-radius:16px;background:#f0f5f1;margin:70px 0 20px}.pi-source-reading h2{font-size:30px;letter-spacing:-.02em}.pi-source-reading details{border-top:1px solid #ccd9cf;padding:18px 0}.pi-source-reading summary{cursor:pointer;font-size:17px;font-weight:600;line-height:1.5}.pi-source-reading details p{font-size:15px;line-height:1.8;max-width:850px}.pi-source-detail{display:block;background:linear-gradient(110deg,#e8f0e7,#efebf6);padding:44px}.pi-source-detail h1{font-size:clamp(36px,5vw,64px);max-width:1000px}.pi-source-detail .lede{font-size:23px}.pi-source-tags{display:flex;flex-wrap:wrap;gap:10px;margin-top:25px}.pi-source-tags span{font-size:12px;padding:7px 12px;border:1px solid #c0cbc0;border-radius:20px;background:#ffffff80}.pi-source-jumps{display:flex;flex-wrap:wrap;gap:10px;padding:5px 0 14px}.pi-source-jumps a{font-size:14px;text-decoration:none;padding:10px 16px;border:1px solid #a9bfb0;border-radius:7px}.pi-section-number{font:10px monospace!important;letter-spacing:.12em;color:#5f7066;margin-bottom:16px}.pi-source-index .pi-question-grid>section{scroll-margin-top:48px}.pi-source-index a:focus-visible,.pi-source-index button:focus-visible,.pi-source-index summary:focus-visible{outline:3px solid #af8248;outline-offset:4px}.pi-source-index .pi-source-context{font-size:15px;line-height:1.65}
@media(prefers-reduced-motion:reduce){.pi-source-card,.pi-source-guide-grid>a{transition:none;transform:none!important}}
@media(max-width:900px){.pi-source-hero{gap:24px;grid-template-columns:minmax(0,1fr) 230px}.pi-library-stats{padding:22px}.pi-library-stats>strong{font-size:76px}.pi-source-guide-grid{gap:12px}.pi-source-guide-grid>a{padding:22px 20px 42px}.pi-source-guide-grid h2{font-size:21px}}
@media(max-width:650px){.pi-source-hero{grid-template-columns:1fr;padding:28px 24px;border-radius:16px}.pi-source-hero h1{font-size:48px}.pi-library-stats{transform:none;display:grid;grid-template-columns:1fr 1fr;gap:0 18px;padding:22px}.pi-stat-label{grid-column:1/-1}.pi-library-stats>strong{font-size:72px;grid-column:1;margin:12px 0 0}.pi-library-stats>span:not(.pi-stat-label):not(.pi-stat-date){grid-column:1;font-size:14px}.pi-library-stats>div{grid-column:2;grid-row:2/4;border:0;margin:0;padding:0}.pi-library-stats p{font-size:11px;gap:8px}.pi-library-stats b{font-size:22px;min-width:26px}.pi-stat-date{grid-column:1/-1}.pi-source-guide-grid{grid-template-columns:1fr;margin-bottom:48px}.pi-source-guide-grid h2{font-size:25px;margin:13px 0 10px}.pi-source-guide-grid>a{padding:24px 26px 34px}.pi-source-toolbar{grid-template-columns:1fr;padding:20px;gap:18px}.pi-source-alphabet{flex-wrap:nowrap;overflow-x:auto;padding-bottom:14px}.pi-source-alphabet button{flex-shrink:0}.pi-source-result-bar{gap:10px}.pi-source-result-bar p{font-size:12px}.pi-source-reading{padding:25px;margin-top:48px}.pi-source-reading h2{font-size:27px}.pi-source-detail h1{font-size:40px}.pi-source-detail .lede{font-size:20px}.pi-source-jumps a{font-size:12px;padding:9px 11px}.pi-source-card{min-height:170px}.pi-source-browser h2{font-size:33px}}
/* Single-column protocol articles, September 2026 */
.pi-protocol-article{max-width:1000px;margin:0 auto}.pi-protocol-article .pi-source-detail{padding:38px;background:linear-gradient(125deg,#e3f1f5,#edf1f9 60%,#f5e9e6);border:1px solid #cbdde7}.pi-protocol-article .pi-source-detail h1{font-size:clamp(34px,4vw,58px);line-height:1.12}.pi-protocol-article .pi-source-detail p:not(.eyebrow):not(.lede){font-size:17px;line-height:1.75;max-width:780px}.pi-article-section{margin:30px 0;border:1px solid #d1dfe6;border-radius:17px;background:#fff;overflow:hidden;scroll-margin-top:36px;box-shadow:0 7px 24px #21445c06}.pi-article-section>header{position:relative;display:flex;align-items:center;gap:22px;min-height:102px;padding:25px 32px;background:linear-gradient(110deg,#e7f2f8,#edf1f9);border-bottom:1px solid #d0e1eb}.pi-article-section:nth-of-type(2)>header{background:linear-gradient(110deg,#e8f4eb,#eef7ed)}.pi-article-section:nth-of-type(4)>header{background:linear-gradient(110deg,#fff0de,#fff7eb)}.pi-article-section:nth-of-type(5)>header{background:linear-gradient(110deg,#eee9f9,#f4f1fa)}.pi-chapter-number{display:flex;align-items:center;justify-content:center;flex:0 0 44px;height:44px;border-radius:12px 12px 12px 0;background:#fa715e;color:#fff;font-weight:700;font-size:16px}.pi-article-section h2{margin:0;color:#234d68;font-size:clamp(23px,2.4vw,30px);line-height:1.25;letter-spacing:-.025em}.pi-chapter-body{padding:30px 36px;color:#29485c}.pi-chapter-body p,.pi-chapter-body li{font-size:17px;line-height:1.8}.pi-chapter-body h3{margin:28px 0 12px;font-size:21px;color:#264d60}.pi-chapter-body h3:first-child{margin-top:0}.pi-protocol-facts{margin:20px 0}.pi-protocol-facts>div{padding:15px 0;border-bottom:1px solid #e2e9ee}.pi-protocol-facts dt{font-size:12px;font-weight:700;text-transform:uppercase;letter-spacing:.07em;color:#5f7380}.pi-protocol-facts dd{margin:6px 0 0;font-size:18px;line-height:1.6}.pi-research-results{padding-left:25px;margin:22px 0}.pi-research-results li{padding-left:6px;margin-bottom:24px}.pi-research-results li::marker{color:#28728d}.pi-research-results sup{font-size:12px;white-space:nowrap}.pi-research-results sup a{text-decoration:none;color:#147fba}.pi-results-intro{color:#506e81}.pi-reference-list{padding-left:28px}.pi-reference-list li{padding:9px 0 9px 6px;border-bottom:1px solid #e7edf1;scroll-margin-top:50px}.pi-reference-list li:target{background:#fff1c9}.pi-label-context{padding:18px;background:#f2f5f7;border-radius:10px;margin-top:22px}.pi-label-context summary{cursor:pointer;font-weight:600}.pi-supply-planner{margin:25px 0;padding:24px;background:#f3f8f4;border:1px solid #d6e5d9;border-radius:12px}.pi-supply-planner label{display:block;font-weight:600;font-size:14px;margin-bottom:8px}.pi-supply-planner input{font:inherit;padding:12px;border:1px solid #9cb6a7;border-radius:6px;width:100%;max-width:350px;background:#fff;color:#244e3b}.pi-supply-planner .pi-dose-table th{background:#e1eee5}.pi-vial-count{font-weight:700;color:#285d45}.pi-planner-note,.pi-planner-status{font-size:14px!important}.pi-source-index>.pi-source-hero{display:block;max-width:1000px;margin-left:auto;margin-right:auto}.pi-source-index>.pi-review-note,.pi-source-browser{max-width:1000px;margin-left:auto;margin-right:auto}.pi-source-index .pi-protocol-grid{grid-template-columns:1fr;gap:12px}.pi-source-index .pi-source-card{min-height:0;padding:20px 26px;border-top-width:1px;border-left-width:5px}.pi-source-index .pi-source-card h3{margin:8px 0;font-size:23px}.pi-source-index .pi-source-card[data-status=single]{border-left-color:#789d85}.pi-source-index .pi-source-card[data-status=blend]{border-left-color:#a58bbf}.pi-source-index .pi-source-card[data-status=stack]{border-left-color:#bf995d}.pi-question-grid{grid-template-columns:1fr}.pi-protocol-article .pi-dose-table th{background:#e6eff5}.pi-protocol-article .pi-dose-table td,.pi-protocol-article .pi-dose-table th{padding:13px 14px;border-color:#d5e2ea}.pi-protocol-article .pi-source-jumps{margin:25px 0}.pi-protocol-article a{color:#24647b}.pi-supply-planner input:focus-visible{outline:3px solid #b48742;outline-offset:3px}@media(max-width:600px){.pi-chapter-body{padding:22px 19px}.pi-article-section>header{padding:20px 17px;gap:13px;min-height:88px}.pi-chapter-number{flex-basis:35px;height:38px;font-size:14px}.pi-chapter-body p,.pi-chapter-body li{font-size:16px;line-height:1.75}.pi-protocol-article .pi-source-detail{padding:25px 21px}.pi-supply-planner{padding:16px}.pi-protocol-article .pi-dose-table th,.pi-protocol-article .pi-dose-table td{padding:10px 8px;font-size:13px}.pi-protocol-facts dd{font-size:16px}.pi-source-index .pi-source-card{padding:17px 20px}.pi-source-index .pi-source-toolbar{grid-template-columns:1fr}}
.pi-protocol-article .pi-research-results{list-style:disc outside!important}.pi-protocol-article .pi-reference-list{list-style:decimal outside!important}.pi-protocol-article .pi-research-results>li,.pi-protocol-article .pi-reference-list>li{display:list-item!important}.pi-protocol-article .pi-article-section h2{font-weight:700}
.pi-reference-context{display:block;font-size:12px;line-height:1.6;color:#5b6a72;margin-top:5px}